Across TCGA pan-cancer cohorts, PTPRD-AS2 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of PTPRD-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PTPRD-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types PTPRD-AS2 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD and LUSC are the cancer types where PTPRD-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTPRD-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	−0.076	.001	4	view →
LUSC	All	II,III,IV	−0.024	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: PTPRD-AS2 RNA expression & survival · all PTPRD-AS2 data types