PTPRC

Across TCGA pan-cancer cohorts, PTPRC mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated PTPRC data layer compared with 23 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PTPRC mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PTPRC expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

COAD, LUAD, and PDAC are the cancer types where PTPRC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.822	1.000	.021	66	view →
LUAD	DFS	Tertile	All	0.840	0.443	.005	20	view →
PDAC	DFS	Median	II,III,IV	0.579	0.873	.005	16	view →
HNSC	DFS	Tertile	All	0.906	1.000	.009	6	view →
UCEC	OS	Median	II,III,IV	1.000	0.620	.011	4	view →
LSCC	OS	Tertile	III,IV	1.000	0.766	.038	4	view →
CCRCC	OS	Median	IV	0.167	0.784	.038	2	view →
GBM	OS	Quartile	All	0.243	0.426	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

PTPRC–COAD (DFS)

Open the COAD breakdown →