PTPRC

Across TCGA pan-cancer cohorts, PTPRC mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of PTPRC’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PTPRC mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PTPRC is over-expressed in tumor.

HNSC, CCRCC, and PDAC are the cancer types where PTPRC tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTPRC mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.662	<.001	12	view →
CCRCC	Male	IV	+1.416	<.001	11	view →
PDAC	Female	All	+0.841	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

PTPRC–HNSC

Open the HNSC breakdown →