PTPRC

Across TCGA patient cohorts, PTPRC protein abundance is significantly associated with the RNA expression of many other genes, with 20,953 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PTPRC-associated genes across cancer lineages are CYTH4, CSF2RB, and IL2RB. Each is linked with PTPRC in more than 9 cancer types. Because this analysis shows association rather than direction, both PTPRC-to-partner and partner-to-PTPRC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTPRC versus CYTH4 in GBM, with a Pearson correlation of 0.91.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRC→partner) and Y-score (partner→PTPRC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CYTH4 →	+1.298	+0.923	<.001	<.001	3	10
HNSC	CSF2RB →	+1.315	+0.848	<.001	<.001	3	10
BRCA	IL2RB →	+1.270	+0.705	<.001	<.001	3	10
BRCA	SLA2 →	+1.113	+0.811	<.001	<.001	3	10
UCEC	SIRPB1 →	+0.802	+0.829	<.001	<.001	3	10
GBM	HCK →	+1.367	+0.952	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,953 associations by consensus.

PTPRC vs CYTH4 — GBM

Explore this scatter interactively →