PTPRC

Across TCGA patient cohorts, PTPRC mutation is significantly associated with the RNA expression of many other genes, with 5,785 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRC-associated genes across cancer lineages are RAD51, MED8, and UBE2T. Each is linked with PTPRC in more than 5 cancer types. Because this analysis shows association rather than direction, both PTPRC-to-partner and partner-to-PTPRC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by PTPRC-low versus PTPRC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRC→partner) and Y-score (partner→PTPRC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD51 →	+0.771	+2.140	<.001	<.001	3	6
LUAD	MED8 →	+0.274	+2.824	.001	.001	3	6
LUAD	UBE2T →	+0.733	+1.819	<.001	.002	3	5
LUAD	RANBP1 →	+0.425	+2.044	.001	.005	3	5
UCEC	RFC5 →	+0.525	+1.583	<.001	<.001	3	5
UCEC	GINS2 →	+0.904	+1.960	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,785 associations by consensus.

RAD51 by PTPRC expression — UCEC

Explore this box plot interactively →