PTPRC

Across TCGA patient cohorts, PTPRC mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRC-associated genes across cancer lineages are c-Kit, 4E-BP1, and TFRC. Each is linked with PTPRC in more than 3 cancer types. Because this analysis shows association rather than direction, both PTPRC-to-partner and partner-to-PTPRC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by PTPRC-low versus PTPRC-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRC→partner) and Y-score (partner→PTPRC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	c-Kit →	-0.411	-3.169	.034	.018	3	4
BLCA	4E-BP1 →	+0.350	+2.187	.005	.034	3	3
LUAD	TFRC →	+0.476	+3.000	.025	.034	3	3
SKCM	Src →	-0.156	-1.473	.026	.005	3	3
UCEC	PCNA →	+0.180	+1.485	.004	.003	3	3
LUAD	INPP4B →	-0.428	-1.683	.012	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

c-Kit by PTPRC expression — LUAD

Explore this box plot interactively →