PTPRA

Across TCGA patient cohorts, PTPRA mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRA-associated genes across cancer lineages are MEK1, Di-Ras3, and ERK2. Each is linked with PTPRA in more than 2 cancer types. Because this analysis shows association rather than direction, both PTPRA-to-partner and partner-to-PTPRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PTPRA-low versus PTPRA-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRA→partner) and Y-score (partner→PTPRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MEK1 →	+0.331	+2.824	.001	.034	3	3
UCEC	Di-Ras3 →	-0.092	-1.893	.043	.014	3	3
UCEC	ERK2 →	+0.129	+1.765	.028	.013	3	2
UCEC	mTOR_pS2448 →	-0.131	-1.986	.004	.008	3	2
COAD	PCNA →	+0.274	+3.008	.033	.019	3	2
UCEC	PKC-delta_pS664 →	-0.088	-2.087	.016	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

MEK1 by PTPRA expression — COAD

Explore this box plot interactively →