PTPN9

Across TCGA cell cohorts, PTPN9 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPN9-associated genes across cancer lineages are C16orf92, SPINK9, and CLPS. Each is linked with PTPN9 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN9-to-partner and partner-to-PTPN9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C16orf92 grouped by PTPN9-low versus PTPN9-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN9→partner) and Y-score (partner→PTPN9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C16orf92 →	+0.056	+5.415	<.001	.004	3	1
SKIN	SPINK9 →	+0.058	+5.415	<.001	.004	3	1
LARGE_INTESTINE	CLPS →	+0.378	+2.688	.003	.008	3	1
LARGE_INTESTINE	SOX17 →	+0.034	+3.791	<.001	.003	3	1
LARGE_INTESTINE	FAM205A →	+0.024	+3.444	<.001	.001	3	1
LUNG_NSCLC_LUAD	RBMY1B →	+0.734	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

C16orf92 by PTPN9 expression — SKIN

Explore this box plot interactively →