PTPN7

Across TCGA pan-cancer cohorts, PTPN7 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PTPN7 data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher PTPN7 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PTPN7 expression acts as an unfavorable survival marker.

CESC, HNSC, and PRAD are the cancer types where PTPN7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	II,III,IV	0.068	0.830	<.001	30	view →
HNSC	OS	Median	IV	0.051	0.708	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SKCM	DFS	Median	All	0.085	0.213	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PTPN7–CESC (OS)

Open the CESC breakdown →