PTPN7

Across TCGA patient cohorts, PTPN7 protein abundance is significantly associated with the RNA expression of many other genes, with 19,436 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PTPN7-associated genes across cancer lineages are CYTH4, GRAP2, and NCF4. Each is linked with PTPN7 in more than 9 cancer types. Because this analysis shows association rather than direction, both PTPN7-to-partner and partner-to-PTPN7 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTPN7 versus CYTH4 in UCEC, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN7→partner) and Y-score (partner→PTPN7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CYTH4 →	+1.050	+0.533	<.001	<.001	3	10
OV	GRAP2 →	+0.841	+0.785	<.001	<.001	3	10
GBM	NCF4 →	+1.081	+0.514	<.001	<.001	3	10
COAD	CSF2RB →	+1.264	+0.694	<.001	<.001	3	10
OV	IL2RB →	+1.367	+0.657	<.001	<.001	3	10
BRCA	SLA2 →	+1.104	+0.622	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,436 associations by consensus.

PTPN7 vs CYTH4 — UCEC

Explore this scatter interactively →