PTPN7

Across TCGA patient cohorts, PTPN7 mutation is significantly associated with the RNA expression of many other genes, with 583 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPN7-associated genes across cancer lineages are CDT1, PSMD12P1, and RN7SL865P. Each is linked with PTPN7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN7-to-partner and partner-to-PTPN7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDT1 grouped by PTPN7-low versus PTPN7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN7→partner) and Y-score (partner→PTPN7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDT1 →	+0.596	+3.191	.009	.009	3	2
SKCM	PSMD12P1 →	+0.033	+2.207	.003	.003	3	2
SKCM	RN7SL865P →	+0.026	+3.810	<.001	.008	3	2
HNSC	BTG3P1 →	+0.088	+4.425	<.001	.006	3	2
BRCA	RN7SL372P →	+1.405	+5.122	<.001	.008	3	2
BRCA	RPL7L1P7 →	+0.107	+6.786	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 583 associations by consensus.

CDT1 by PTPN7 expression — UCEC

Explore this box plot interactively →