PTPN7

Across TCGA cell cohorts, PTPN7 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,313 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTPN7-associated GO terms across cancer lineages are mRNA splice site recognition, Positive regulation of organelle assembly, and Signal transduction in response to DNA damage. Each is linked with PTPN7 in more than 6 cancer types. Because this analysis shows association rather than direction, both PTPN7-to-partner and partner-to-PTPN7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA splice site recognition grouped by PTPN7-low versus PTPN7-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN7→partner) and Y-score (partner→PTPN7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	mRNA splice site recognition →	+0.083	+0.131	<.001	.004	3	7
BLOOD_Leukemia	Positive regulation of organelle assembly →	+0.047	+0.992	<.001	.001	3	7
PANCREAS	Signal transduction in response to DNA damage →	+0.074	+0.189	<.001	.003	3	7
OESOPHAGUS	Positive regulation of calcium ion import →	-0.171	-0.244	.002	.008	3	6
UPPER_AERODIGESTIVE_TRACT	Neutrophil-mediated killing of fungus →	+0.208	+0.188	.002	.002	3	6
BLOOD_Leukemia	Schwann cell differentiation →	+0.097	+1.307	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,313 associations by consensus.

mRNA splice site recognition by PTPN7 expression — PANCREAS

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