PTPN6

Across TCGA pan-cancer cohorts, PTPN6 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PTPN6 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PTPN6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PTPN6 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

COAD, HNSC, and PDAC are the cancer types where PTPN6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.884	1.000	.039	24	view →
HNSC	DFS	Tertile	II,III,IV	0.888	0.989	.023	11	view →
PDAC	OS	Tertile	II,III,IV	0.640	0.957	.004	10	view →
GBM	OS	Quartile	All	0.384	0.712	.009	9	view →
LUAD	DFS	Median	All	0.725	0.550	.038	6	view →
UCEC	OS	Tertile	II,III,IV	1.000	0.514	.021	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PTPN6–COAD (DFS)

Open the COAD breakdown →