PTPN6

Across TCGA patient cohorts, PTPN6 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPN6-associated genes across cancer lineages are MSH2, EGFR_pY1068, and A-Raf_pS299. Each is linked with PTPN6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN6-to-partner and partner-to-PTPN6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by PTPN6-low versus PTPN6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN6→partner) and Y-score (partner→PTPN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.234	-2.973	.014	.035	3	2
UCEC	EGFR_pY1068 →	-0.289	-1.807	.005	.027	3	1
UCEC	A-Raf_pS299 →	-0.193	-3.321	<.001	.009	3	1
UCEC	ERK2 →	+0.191	+1.807	.016	.027	3	1
UCEC	Lck →	+0.285	+2.321	<.001	.033	3	1
UCEC	p62 Lck ligand →	+0.406	+4.087	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

MSH2 by PTPN6 expression — UCEC

Explore this box plot interactively →