PTPN6

Across TCGA cell cohorts, PTPN6 mutation is significantly associated with the RNA expression of many other genes, with 596 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPN6-associated genes across cancer lineages are FAM160A1, OR2B11, and IL4. Each is linked with PTPN6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN6-to-partner and partner-to-PTPN6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM160A1 grouped by PTPN6-low versus PTPN6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN6→partner) and Y-score (partner→PTPN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FAM160A1 →	+0.267	+3.385	.001	.008	3	2
BREAST	OR2B11 →	+0.012	+4.963	<.001	.001	3	1
BLOOD_Leukemia	IL4 →	+1.532	+3.007	<.001	.007	3	1
BLOOD_Leukemia	BHLHE23 →	+1.113	+3.409	.001	.008	3	1
BLOOD_Leukemia	DCDC2 →	+0.397	+3.520	<.001	.005	3	1
BLOOD_Leukemia	NPFFR1 →	+0.011	+3.359	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 596 associations by consensus.

FAM160A1 by PTPN6 expression — BLOOD_Leukemia

Explore this box plot interactively →