PTPN5

Across TCGA pan-cancer cohorts, PTPN5 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated PTPN5 data layer compared with 26 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PTPN5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PTPN5 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

KIRP, OV, and LGG are the cancer types where PTPN5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.176	0.885	<.001	24	view →
OV	DFS	Median	All	0.104	0.541	<.001	18	view →
LGG	OS	Median	All	0.208	0.896	<.001	12	view →
READ	OS	Median	III,IV	0.644	0.932	<.001	10	view →
LUAD	OS	Median	III,IV	0.223	0.677	.006	9	view →
SKCM	DFS	Median	II,III,IV	0.801	0.555	.019	9	view →
SCLC	OS	Median	All	0.082	0.822	<.001	6	view →
LIHC	OS	Median	III,IV	0.118	0.615	.003	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

PTPN5–KIRP (OS)

Open the KIRP breakdown →