PTPN5

Across TCGA patient cohorts, PTPN5 protein abundance is significantly associated with the RNA expression of many other genes, with 4,541 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PTPN5-associated genes across cancer lineages are FUT9, HS6ST3, and PNRC2. Each is linked with PTPN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN5-to-partner and partner-to-PTPN5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTPN5 versus FUT9 in GBM, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN5→partner) and Y-score (partner→PTPN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FUT9 →	+1.873	+0.892	<.001	<.001	3	2
GBM	HS6ST3 →	+1.088	+0.653	<.001	<.001	3	2
OV	PNRC2 →	+0.625	+3.324	.004	.001	3	2
OV	STAG2 →	+0.625	+3.379	.005	<.001	3	1
OV	NNT →	-0.705	-3.585	.007	.002	3	1
OV	VAX2 →	-1.390	-3.515	.008	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,541 associations by consensus.

PTPN5 vs FUT9 — GBM

Explore this scatter interactively →