PTPN5

Across TCGA patient cohorts, PTPN5 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPN5-associated genes across cancer lineages are PCNA, Shc_pY317, and 4E-BP1. Each is linked with PTPN5 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTPN5-to-partner and partner-to-PTPN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PTPN5-low versus PTPN5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN5→partner) and Y-score (partner→PTPN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.274	+3.058	<.001	<.001	3	3
UCEC	Shc_pY317 →	-0.160	-1.874	.001	.002	3	2
UCEC	4E-BP1 →	+0.270	+3.700	.002	.001	3	2
SKCM	Heregulin →	+0.147	+2.012	.032	.017	3	2
UCEC	14-3-3_beta →	-0.083	-2.088	.013	.016	3	1
UCEC	eEF2 →	+0.349	+2.000	.003	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

PCNA by PTPN5 expression — UCEC

Explore this box plot interactively →