PTPN5

Across TCGA cell cohorts, PTPN5 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,961 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PTPN5-associated GO terms across cancer lineages are Regulation of macroautophagy, Negative regulation of myoblast fusion, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with PTPN5 in more than 8 cancer types. Because this analysis shows association rather than direction, both PTPN5-to-partner and partner-to-PTPN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of macroautophagy grouped by PTPN5-low versus PTPN5-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN5→partner) and Y-score (partner→PTPN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of macroautophagy →	+0.041	+0.591	<.001	.005	3	9
LUNG_NSCLC_LUAD	Negative regulation of myoblast fusion →	+0.074	+0.029	<.001	.007	3	8
LUNG_NSCLC_LUAD	Negative regulation of syncytium formation by plasma membrane fusion →	+0.070	+0.029	<.001	.007	3	7
BONE	RNA splicing, via transesterification reactions →	+0.073	+1.333	<.001	.005	3	7
BONE	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.074	+1.319	<.001	.006	3	7
BONE	mRNA splicing, via spliceosome →	+0.074	+1.319	<.001	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,961 associations by consensus.

Regulation of macroautophagy by PTPN5 expression — LUNG_SCLC

Explore this box plot interactively →