PTPN5

Across TCGA cell cohorts, PTPN5 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPN5-associated genes across cancer lineages are NXNL1, OR9I1, and SERPINB12. Each is linked with PTPN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN5-to-partner and partner-to-PTPN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NXNL1 grouped by PTPN5-low versus PTPN5-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN5→partner) and Y-score (partner→PTPN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	NXNL1 →	+0.023	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	OR9I1 →	+0.012	+4.736	<.001	.009	3	1
LUNG_NSCLC_LUAD	SERPINB12 →	+0.088	+3.695	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR8B8 →	+0.017	+3.564	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR8B4 →	+0.015	+3.472	.004	.004	3	1
BLOOD_Leukemia	C1QTNF8 →	+0.028	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

NXNL1 by PTPN5 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →