PTPN4

Across TCGA patient cohorts, PTPN4 RNA expression is significantly associated with the protein abundance of many other proteins, with 20,962 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PTPN4-associated proteins across cancer lineages are HNRNPLL, PPP1R18_S368, and DDX21_S121. Each is linked with PTPN4 in more than 5 cancer types. Because this analysis shows association rather than direction, both PTPN4-to-partner and partner-to-PTPN4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTPN4 versus HNRNPLL in HNSC, with a Pearson correlation of 0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN4→partner) and Y-score (partner→PTPN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HNRNPLL →	+0.246	+0.572	<.001	<.001	3	6
UCEC	PPP1R18_S368 →	-0.736	-0.643	<.001	<.001	3	5
LUAD	DDX21_S121 →	-0.704	-0.557	<.001	<.001	3	5
LSCC	TSN →	+0.408	+0.564	<.001	<.001	3	5
GBM	BCL3_S41 →	-0.468	-0.531	.001	.001	3	4
GBM	BIN2_S444 →	-0.721	-0.589	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,962 associations by consensus.

PTPN4 vs HNRNPLL — HNSC

Explore this scatter interactively →