PTPN4

Across TCGA patient cohorts, PTPN4 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPN4-associated genes across cancer lineages are FoxM1, beta-Catenin, and Caspase-7-cleavedD198. Each is linked with PTPN4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTPN4-to-partner and partner-to-PTPN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by PTPN4-low versus PTPN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN4→partner) and Y-score (partner→PTPN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.173	+1.459	.039	.012	3	3
UCEC	beta-Catenin →	+0.366	+1.459	.026	.012	3	3
UCEC	Caspase-7-cleavedD198 →	+0.596	+2.107	.001	.002	3	3
BLCA	Tuberin →	+0.453	+3.169	.010	.019	3	2
BLCA	Cyclin-E2 →	+0.256	+3.169	.004	.019	3	2
UCEC	14-3-3_beta →	-0.084	-1.780	.009	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

FoxM1 by PTPN4 expression — UCEC

Explore this box plot interactively →