PTPN4

Across TCGA cell cohorts, PTPN4 mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPN4-associated genes across cancer lineages are BTNL2, OR10H5, and C16orf82. Each is linked with PTPN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN4-to-partner and partner-to-PTPN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BTNL2 grouped by PTPN4-low versus PTPN4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN4→partner) and Y-score (partner→PTPN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	BTNL2 →	+0.077	+3.760	<.001	.008	3	2
SKIN	OR10H5 →	+0.012	+4.977	<.001	.007	3	1
SKIN	C16orf82 →	+0.016	+4.977	<.001	.007	3	1
LARGE_INTESTINE	SH3GL2 →	+1.199	+3.252	.001	.009	3	1
LUNG_NSCLC_LUAD	CLEC4M →	+0.031	+3.807	.005	.007	3	1
LUNG_NSCLC_LUAD	GTSF1L →	+0.037	+3.544	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

BTNL2 by PTPN4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →