PTPN3

Across TCGA patient cohorts, PTPN3 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPN3-associated genes across cancer lineages are ATM, c-Kit, and p90 RSK. Each is linked with PTPN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTPN3-to-partner and partner-to-PTPN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PTPN3-low versus PTPN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN3→partner) and Y-score (partner→PTPN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.509	-1.485	<.001	.003	3	3
UCEC	c-Kit →	-0.159	-1.295	.018	.010	3	3
SKCM	p90 RSK →	+0.240	+2.321	.010	.032	3	2
UCEC	Caspase-8 →	-0.238	-2.847	.001	<.001	3	2
UCEC	GAPDH →	+0.370	+2.087	.017	.004	3	2
UCEC	JNK2 →	+0.245	+4.026	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

ATM by PTPN3 expression — UCEC

Explore this box plot interactively →