PTPN22

Across TCGA patient cohorts, PTPN22 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPN22-associated genes across cancer lineages are PDCD4, STAT3_pY705, and Notch1. Each is linked with PTPN22 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTPN22-to-partner and partner-to-PTPN22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by PTPN22-low versus PTPN22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN22→partner) and Y-score (partner→PTPN22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.363	-1.584	.007	.032	3	3
UCEC	STAT3_pY705 →	-0.302	-1.247	<.001	.038	3	3
UCEC	Notch1 →	+0.100	+1.778	.014	.007	3	2
UCEC	Rad50 →	-0.201	-2.401	.004	.002	3	2
UCEC	S6_pS240_S244 →	+0.273	+1.847	.021	.007	3	2
UCEC	ASNS →	+0.386	+2.137	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

PDCD4 by PTPN22 expression — UCEC

Explore this box plot interactively →