PTPN22

Across TCGA cell cohorts, PTPN22 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,349 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PTPN22-associated GO terms across cancer lineages are Integrin-mediated signaling pathway, Urokinase plasminogen activator signaling pathway, and Regulation of collagen metabolic process. Each is linked with PTPN22 in more than 8 cancer types. Because this analysis shows association rather than direction, both PTPN22-to-partner and partner-to-PTPN22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Integrin-mediated signaling pathway grouped by PTPN22-low versus PTPN22-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN22→partner) and Y-score (partner→PTPN22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Integrin-mediated signaling pathway →	+0.109	+0.879	<.001	<.001	3	9
SOFT_TISSUE	Urokinase plasminogen activator signaling pathway →	+0.700	+0.824	<.001	<.001	3	8
SOFT_TISSUE	Regulation of collagen metabolic process →	+0.161	+1.025	<.001	<.001	3	8
LIVER	Positive regulation of leukocyte migration →	+0.147	+0.469	.001	.008	3	8
OVARY	Negative regulation of protein export from nucleus →	+0.151	+0.662	<.001	.003	3	8
SOFT_TISSUE	Positive regulation of cell-substrate junction organization →	+0.133	+1.114	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,349 associations by consensus.

Integrin-mediated signaling pathway by PTPN22 expression — SOFT_TISSUE

Explore this box plot interactively →