PTPN22

Across TCGA cell cohorts, PTPN22 mutation is significantly associated with the RNA expression of many other genes, with 55 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTPN22-associated genes across cancer lineages are C6orf118, UGT2B10, and OR10Q1. Each is linked with PTPN22 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN22-to-partner and partner-to-PTPN22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by PTPN22-low versus PTPN22-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN22→partner) and Y-score (partner→PTPN22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C6orf118 →	+0.053	+3.772	<.001	<.001	3	2
PANCREAS	UGT2B10 →	+0.413	+5.000	<.001	.006	3	1
PANCREAS	OR10Q1 →	+0.033	+5.614	<.001	.002	3	1
LUNG_SCLC	CCL7 →	+0.325	+4.044	<.001	.009	3	1
LUNG_SCLC	ADH7 →	+0.048	+4.044	.006	.009	3	1
LUNG_SCLC	PNLIPRP3 →	+0.011	+4.523	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

C6orf118 by PTPN22 expression — BLOOD_Leukemia

Explore this box plot interactively →