Across TCGA patient cohorts, PTPN20 mutation is significantly associated with the RNA expression of many other genes, with 2,018 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPN20-associated genes across cancer lineages are UBE2F-SCLY, HTRA2, and TUBGCP2. Each is linked with PTPN20 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN20-to-partner and partner-to-PTPN20 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN20→partner) and Y-score (partner→PTPN20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	UBE2F-SCLY →	+0.058	+3.429	.002	.006	3	2
SKCM	HTRA2 →	+0.588	+3.379	<.001	.005	3	2
SKCM	TUBGCP2 →	+0.637	+3.378	<.001	.004	3	2
SKCM	ACTR1A →	+0.441	+3.341	.007	.005	3	2
SKCM	FDPS →	+0.552	+3.328	.007	.005	3	2
SKCM	RRP12 →	+0.675	+3.328	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,018 associations by consensus.

Exploration

PTPN20 survival (RNA) · tumor vs normal (RNA) · all PTPN20 data types