Across TCGA patient cohorts, PTPN20 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPN20-associated genes across cancer lineages are Rad50, Tuberin_pT1462, and C-Raf. Each is linked with PTPN20 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN20-to-partner and partner-to-PTPN20 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN20→partner) and Y-score (partner→PTPN20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.194	-2.321	.041	.034	3	2
UCEC	Tuberin_pT1462 →	+0.279	+2.331	.002	.003	3	2
UCEC	C-Raf →	+0.156	+2.000	.005	.030	3	2
UCEC	14-3-3_beta →	-0.107	-2.558	.006	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.133	-2.321	.044	.034	3	1
UCEC	JNK2 →	+0.230	+3.348	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

PTPN20 survival (RNA) · tumor vs normal (RNA) · all PTPN20 data types