PTPN2

Across TCGA patient cohorts, PTPN2 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,180 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PTPN2-associated proteins across cancer lineages are RNMT, SMCHD1, and PTPN2_S304. Each is linked with PTPN2 in more than 8 cancer types. Because this analysis shows association rather than direction, both PTPN2-to-partner and partner-to-PTPN2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTPN2 versus RNMT in HNSC, with a Pearson correlation of 0.47.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN2→partner) and Y-score (partner→PTPN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNMT →	+0.372	+0.590	<.001	<.001	3	9
BRCA	SMCHD1 →	+0.339	+0.355	<.001	<.001	3	8
BRCA	PTPN2_S304 →	+0.977	+0.489	<.001	<.001	3	7
LSCC	PLEKHA6 →	-0.525	-0.288	<.001	.004	3	6
GBM	SPTAN1 →	-0.354	-0.321	<.001	.001	3	5
OV	IL4I1 →	+0.724	+0.435	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,180 associations by consensus.

PTPN2 vs RNMT — HNSC

Explore this scatter interactively →