PTPN2

Across TCGA patient cohorts, PTPN2 protein abundance is significantly associated with the RNA expression of many other genes, with 17,030 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PTPN2-associated genes across cancer lineages are FPR2, SEH1L, and KIF18A. Each is linked with PTPN2 in more than 7 cancer types. Because this analysis shows association rather than direction, both PTPN2-to-partner and partner-to-PTPN2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTPN2 versus FPR2 in GBM, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN2→partner) and Y-score (partner→PTPN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FPR2 →	+1.134	+0.280	<.001	<.001	3	8
HNSC	SEH1L →	+0.587	+0.433	<.001	<.001	3	7
HNSC	KIF18A →	+0.778	+0.333	<.001	<.001	3	7
COAD	AUNIP →	+0.811	+0.344	<.001	<.001	3	7
COAD	CCNB1 →	+0.865	+0.337	<.001	<.001	3	7
BRCA	CXCL13 →	+2.049	+0.331	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,030 associations by consensus.

PTPN2 vs FPR2 — GBM

Explore this scatter interactively →