PTPN2

Across TCGA cell cohorts, PTPN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,388 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PTPN2-associated GO terms across cancer lineages are Negative regulation of macrophage colony-stimulating factor signaling pathway, Regulation of positive thymic T cell selection, and Regulation of mitochondrial transcription. Each is linked with PTPN2 in more than 17 cancer types. Because this analysis shows association rather than direction, both PTPN2-to-partner and partner-to-PTPN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of macrophage colony-stimulating factor signaling pathway grouped by PTPN2-low versus PTPN2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN2→partner) and Y-score (partner→PTPN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of macrophage colony-stimulating factor signaling pathway →	+0.289	+1.168	<.001	<.001	3	18
LUNG_SCLC	Regulation of positive thymic T cell selection →	+0.326	+0.674	.003	<.001	3	15
BREAST	Regulation of mitochondrial transcription →	+0.131	+1.090	<.001	<.001	3	13
BONE	Regulation of centrosome cycle →	+0.071	+0.621	<.001	.001	3	13
BONE	Regulation of centrosome duplication →	+0.081	+0.811	<.001	<.001	3	13
LARGE_INTESTINE	snRNA metabolic process →	+0.057	+0.674	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,388 associations by consensus.

Negative regulation of macrophage colony-stimulating factor signaling pathway by PTPN2 expression — UPPER_AERODIGESTIVE_TRACT

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