PTPN2

Across TCGA cell cohorts, PTPN2 mutation is significantly associated with the RNA expression of many other genes, with 1 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPN2-associated genes across cancer lineages are ACSM6. Each is linked with PTPN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN2-to-partner and partner-to-PTPN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACSM6 grouped by PTPN2-low versus PTPN2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN2→partner) and Y-score (partner→PTPN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACSM6 →	+0.029	+4.169	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 1 strongest of 1 associations by consensus.

ACSM6 by PTPN2 expression — LARGE_INTESTINE

Explore this box plot interactively →