PTPN18

Across TCGA patient cohorts, PTPN18 protein abundance is significantly associated with the RNA expression of many other genes, with 19,577 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PTPN18-associated genes across cancer lineages are CSF2RB, CYTIP, and GBP5. Each is linked with PTPN18 in more than 9 cancer types. Because this analysis shows association rather than direction, both PTPN18-to-partner and partner-to-PTPN18 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTPN18 versus CSF2RB in COAD, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN18→partner) and Y-score (partner→PTPN18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CSF2RB →	+1.150	+0.565	<.001	<.001	3	10
HNSC	CYTIP →	+1.306	+0.587	<.001	<.001	3	10
HNSC	GBP5 →	+1.408	+0.473	<.001	<.001	3	10
BRCA	NKG7 →	+1.552	+0.357	<.001	<.001	3	9
COAD	BCL2A1 →	+2.054	+0.616	<.001	<.001	3	9
COAD	CLEC4E →	+1.202	+0.419	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,577 associations by consensus.

PTPN18 vs CSF2RB — COAD

Explore this scatter interactively →