PTPN18

Across TCGA patient cohorts, PTPN18 mutation is significantly associated with the RNA expression of many other genes, with 1,269 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPN18-associated genes across cancer lineages are MIR548S, RNA5SP457, and LILRB1-AS1. Each is linked with PTPN18 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN18-to-partner and partner-to-PTPN18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548S grouped by PTPN18-low versus PTPN18-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN18→partner) and Y-score (partner→PTPN18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR548S →	+0.400	+5.418	<.001	.005	3	2
LUSC	RNA5SP457 →	+0.354	+3.993	<.001	.005	3	2
LUSC	LILRB1-AS1 →	+0.183	+3.884	<.001	.008	3	2
LUSC	GXYLT1P2 →	+0.126	+4.070	<.001	.004	3	2
LUSC	LINC02663 →	+0.865	+4.350	<.001	.002	3	2
LUSC	UBTFL7 →	+0.504	+4.070	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,269 associations by consensus.

MIR548S by PTPN18 expression — CESC

Explore this box plot interactively →