PTPN18

Across TCGA patient cohorts, PTPN18 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPN18-associated genes across cancer lineages are MEK1, ATM, and EGFR_pY1068. Each is linked with PTPN18 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN18-to-partner and partner-to-PTPN18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PTPN18-low versus PTPN18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN18→partner) and Y-score (partner→PTPN18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.403	+2.662	.003	<.001	3	2
UCEC	ATM →	-0.559	-2.446	<.001	.018	3	2
UCEC	EGFR_pY1068 →	-0.247	-1.700	.008	.042	3	1
UCEC	A-Raf_pS299 →	-0.152	-3.321	<.001	.009	3	1
UCEC	ERK2 →	+0.212	+3.584	.003	.002	3	1
UCEC	GATA6 →	-0.154	-3.155	.013	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

MEK1 by PTPN18 expression — UCEC

Explore this box plot interactively →