PTPN18

Across TCGA cell cohorts, PTPN18 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,977 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PTPN18-associated GO terms across cancer lineages are Sperm motility, Methylglyoxal metabolic process, and Flagellated sperm motility. Each is linked with PTPN18 in more than 10 cancer types. Because this analysis shows association rather than direction, both PTPN18-to-partner and partner-to-PTPN18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sperm motility grouped by PTPN18-low versus PTPN18-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN18→partner) and Y-score (partner→PTPN18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Sperm motility →	-0.119	-1.278	.002	<.001	3	11
OESOPHAGUS	Methylglyoxal metabolic process →	+0.173	+1.419	.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Flagellated sperm motility →	-0.119	-1.278	.002	<.001	3	11
OESOPHAGUS	Glycerophospholipid metabolic process →	+0.042	+1.269	<.001	<.001	3	10
OESOPHAGUS	Fatty acid catabolic process →	+0.104	+1.466	<.001	<.001	3	10
BONE	Regulation of ceramide biosynthetic process →	+0.096	+1.690	.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,977 associations by consensus.

Sperm motility by PTPN18 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →