PTPN18

Across TCGA cell cohorts, PTPN18 mutation is significantly associated with the mutation status of many other genes, with 492 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPN18-associated genes across cancer lineages are CLUAP1, PHF3, and VIL1. Each is linked with PTPN18 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN18-to-partner and partner-to-PTPN18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLUAP1 grouped by PTPN18-low versus PTPN18-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN18→partner) and Y-score (partner→PTPN18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CLUAP1 →	+5.392	+4.824	.004	.004	1	2
SKIN	PHF3 →	+2.807	+4.247	.007	.007	1	2
SKIN	VIL1 →	+4.392	+4.392	.009	.009	1	2
SKIN	ABCG5 →	+4.392	+4.392	.009	.009	1	2
SKIN	TAGLN2 →	+5.392	+4.824	.004	.004	1	2
SKIN	UBXN6 →	+5.392	+4.824	.004	.004	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 492 associations by consensus.

CLUAP1 by PTPN18 expression — SKIN

Explore this box plot interactively →