PTPN11

Across TCGA pan-cancer cohorts, PTPN11 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PTPN11 data layer compared with 23 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PTPN11 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PTPN11 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, HNSC, and LUAD are the cancer types where PTPN11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.862	0.515	<.001	39	view →
HNSC	DFS	Median	IV	0.328	0.889	.014	15	view →
LUAD	DFS	Quartile	All	0.356	0.736	.014	14	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	12	view →
UCEC	OS	Quartile	II,III,IV	0.364	1.000	.027	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PTPN11–LSCC (DFS)

Open the LSCC breakdown →