PTPN11

Across TCGA patient cohorts, PTPN11 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPN11-associated genes across cancer lineages are Snail, Bax, and eEF2. Each is linked with PTPN11 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN11-to-partner and partner-to-PTPN11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Snail grouped by PTPN11-low versus PTPN11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN11→partner) and Y-score (partner→PTPN11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Snail →	-0.177	-2.987	.048	.035	3	2
SKCM	Bax →	+0.259	+3.000	.030	.035	3	2
UCEC	eEF2 →	+0.333	+2.584	.004	.010	3	2
UCEC	EGFR_pY1068 →	-0.289	-2.321	<.001	<.001	3	2
UCEC	ERK2 →	+0.224	+3.999	<.001	<.001	3	2
UCEC	Notch1 →	+0.115	+1.916	.011	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Snail by PTPN11 expression — SKCM

Explore this box plot interactively →