PTPN11

Across TCGA cell cohorts, PTPN11 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,002 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTPN11-associated GO terms across cancer lineages are Positive regulation of mitotic cytokinesis, Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and rRNA 5'-end processing. Each is linked with PTPN11 in more than 14 cancer types. Because this analysis shows association rather than direction, both PTPN11-to-partner and partner-to-PTPN11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitotic cytokinesis grouped by PTPN11-low versus PTPN11-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN11→partner) and Y-score (partner→PTPN11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Positive regulation of mitotic cytokinesis →	+0.161	+0.694	<.001	.005	3	15
LIVER	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.171	+0.531	.001	.002	3	15
LIVER	rRNA 5'-end processing →	+0.171	+0.531	.001	.002	3	15
OVARY	Regulation of microtubule depolymerization →	+0.091	+0.510	<.001	.008	3	14
KIDNEY	Positive regulation of cytokinesis →	+0.137	+0.729	<.001	.004	3	14
UPPER_AERODIGESTIVE_TRACT	CAMP/PKA signal transduction →	+0.218	+0.879	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,002 associations by consensus.

Positive regulation of mitotic cytokinesis by PTPN11 expression — KIDNEY

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