PTPN11

Across TCGA cell cohorts, PTPN11 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPN11-associated genes across cancer lineages are ASB17, C12orf40, and OR4X2. Each is linked with PTPN11 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN11-to-partner and partner-to-PTPN11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by PTPN11-low versus PTPN11-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN11→partner) and Y-score (partner→PTPN11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1
CNS	OR4X2 →	+0.031	+4.981	<.001	.008	3	1
LARGE_INTESTINE	SSMEM1 →	+0.030	+3.707	<.001	.009	3	1
LARGE_INTESTINE	TFDP3 →	+0.037	+4.196	<.001	.002	3	1
LARGE_INTESTINE	CENPVL1 →	+0.182	+4.510	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ASB17 by PTPN11 expression — OVARY

Explore this box plot interactively →