Across TCGA pan-cancer cohorts, PTPN1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PTPN1 data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher PTPN1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PTPN1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUSC, LUAD, and LGG are the cancer types where PTPN1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.079	0.792	<.001	36	view →
LUAD	OS	Median	All	0.223	0.788	.002	21	view →
LGG	OS	Median	All	0.163	0.896	<.001	12	view →
UCEC	DFS	Median	All	0.961	0.620	.020	6	view →
SKCM	DFS	Median	III,IV	0.088	0.613	.018	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: PTPN1 tumor-vs-normal RNA expression · all PTPN1 data types