Across TCGA patient cohorts, PTPN1 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,471 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PTPN1-associated proteins across cancer lineages are RNF114, MOCS3, and OGFR. Each is linked with PTPN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PTPN1-to-partner and partner-to-PTPN1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN1→partner) and Y-score (partner→PTPN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RNF114 →	+0.294	+0.379	<.001	<.001	3	4
COAD	MOCS3 →	+0.283	+0.547	<.001	<.001	3	4
BRCA	OGFR →	+0.301	+0.565	<.001	.001	3	4
COAD	ACOT8 →	+0.330	+0.542	.003	<.001	3	4
LSCC	CEP68 →	-0.342	-0.352	<.001	<.001	3	4
CCRCC	CEBPB →	+0.448	+0.378	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,471 associations by consensus.

Exploration

PTPN1 survival (RNA) · tumor vs normal (RNA) · all PTPN1 data types