Across TCGA patient cohorts, PTPN1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPN1-associated genes across cancer lineages are ERK2, S6_pS235_S236, and ASNS. Each is linked with PTPN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN1-to-partner and partner-to-PTPN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN1→partner) and Y-score (partner→PTPN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.219	+3.321	.002	.009	3	2
UCEC	S6_pS235_S236 →	+0.413	+1.415	.010	.046	3	2
UCEC	ASNS →	+0.530	+2.321	<.001	.005	3	2
UCEC	eEF2 →	+0.316	+1.415	.018	.046	3	1
UCEC	EGFR_pY1068 →	-0.256	-2.700	.006	.006	3	1
UCEC	eIF4E →	+0.164	+2.169	.038	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

PTPN1 survival (RNA) · tumor vs normal (RNA) · all PTPN1 data types