PTPMT1

Across TCGA pan-cancer cohorts, PTPMT1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PTPMT1 data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PTPMT1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PTPMT1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, HNSC, and LUAD are the cancer types where PTPMT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	All	0.931	0.658	.005	37	view →
HNSC	OS	Median	All	0.782	0.915	.018	8	view →
LUAD	DFS	Quartile	III,IV	0.298	0.892	.010	7	view →
PDAC	OS	Median	IV	0.836	0.491	.024	3	view →
GBM	OS	Median	All	0.852	0.681	.006	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PTPMT1–LSCC (OS)

Open the LSCC breakdown →