PTPMT1

Across TCGA patient cohorts, PTPMT1 mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPMT1-associated genes across cancer lineages are MIR3928, MIR4748, and MIR4659A. Each is linked with PTPMT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPMT1-to-partner and partner-to-PTPMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3928 grouped by PTPMT1-low versus PTPMT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPMT1→partner) and Y-score (partner→PTPMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR3928 →	+0.941	+4.386	<.001	.002	3	1
UCEC	MIR4748 →	+1.137	+3.895	<.001	.008	3	1
UCEC	MIR4659A →	+0.786	+4.003	<.001	.005	3	1
UCEC	RPS28P1 →	+0.293	+4.442	<.001	.007	3	1
UCEC	RN7SL733P →	+0.374	+3.943	.002	.007	3	1
UCEC	SNORD116-22 →	+0.468	+4.267	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

MIR3928 by PTPMT1 expression — UCEC

Explore this box plot interactively →