PTPDC1

Across TCGA patient cohorts, PTPDC1 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPDC1-associated genes across cancer lineages are Rab25, eEF2, and GATA6. Each is linked with PTPDC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTPDC1-to-partner and partner-to-PTPDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab25 grouped by PTPDC1-low versus PTPDC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPDC1→partner) and Y-score (partner→PTPDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.402	-2.247	<.001	.001	3	3
UCEC	eEF2 →	+0.329	+1.392	.005	.019	3	2
UCEC	GATA6 →	-0.164	-2.685	.001	.005	3	2
UCEC	PKC-delta_pS664 →	-0.099	-2.321	.012	.005	3	2
UCEC	Chk2_pT68 →	-0.166	-3.880	.006	<.001	3	2
SKCM	Di-Ras3 →	-0.184	-3.000	.009	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Rab25 by PTPDC1 expression — UCEC

Explore this box plot interactively →