PTPDC1

Across TCGA cell cohorts, PTPDC1 mutation is significantly associated with the RNA expression of many other genes, with 600 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPDC1-associated genes across cancer lineages are TCF21, EIF4E1B, and TMEM132C. Each is linked with PTPDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPDC1-to-partner and partner-to-PTPDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCF21 grouped by PTPDC1-low versus PTPDC1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPDC1→partner) and Y-score (partner→PTPDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TCF21 →	+0.008	+3.705	.002	.007	3	1
BLOOD_Leukemia	EIF4E1B →	+0.071	+4.133	<.001	.003	3	1
BLOOD_Leukemia	TMEM132C →	+0.981	+3.551	<.001	.009	3	1
BLOOD_Leukemia	FIGLA →	+0.022	+4.984	<.001	.002	3	1
BLOOD_Leukemia	OR1D5 →	+0.027	+4.384	<.001	.006	3	1
BLOOD_Leukemia	DMRTC1 →	+0.232	+3.855	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 600 associations by consensus.

TCF21 by PTPDC1 expression — BLOOD_Leukemia

Explore this box plot interactively →