Across TCGA pan-cancer cohorts, PTP4A3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PTP4A3 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PTP4A3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PTP4A3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, UCEC, and GBM are the cancer types where PTP4A3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	III,IV	0.972	0.568	.014	14	view →
UCEC	DFS	Median	III,IV	0.162	1.000	.038	8	view →
GBM	OS	Tertile	All	0.933	0.617	.013	5	view →
PDAC	OS	Median	II,III,IV	0.495	0.722	.023	2	view →
HNSC	OS	Quartile	III,IV	0.714	1.000	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: PTP4A3 tumor-vs-normal RNA expression · all PTP4A3 data types